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J Clin Microbiol (1990) 28:140310

15 This review comprehensively introduces the biological role, molecular mechanisms, and progress of ferroptosis in various human diseases

The system x c is a glycoprotein-associated amino acid transporter that catalyzes Na + -independent exchange of extracellular cystine for intracellular glutamate in a 1:1 stoichiometric ratio [12], and in the brain is functionally expressed as a heterodimer [13]