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Preclinical trials conducted on rats demonstrate measurable improvements in transected tendon reattachment and Achilles tendon rupture models, though human clinical data remain limited

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In the NOR test, there was no difference in the time spent exploring the left and right objects during the training phase among the groups (Fig

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Hence, a peptide was designed by substituting the negatively charged residues D42, D48, D49, E51, E56, and D57 within the p53 TAD PEP with alanine to increase its binding affinity to FOXO4 FHD and enhance membrane penetration