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The competitive relationship between NAM methylation and NAD + recycling suggests that NNMT could impede energy expenditure while promoting lipid accumulation

Because the milligram amount is fixed, a lighter body gets more drug exposure per pound: roughly 22% more at 70 kg and about a third less at 120 kg, compared with a 90 kg reference. The dose still comes from response and tolerability, but a lighter person is running a hotter exposure at the same number on the vial

Additionally, it protects the energy producing enzyme Glyceraldehyde 3-phosphate dehydrogenase from attack by nitric oxide.

Impairing blood vessel regulation , contributing to headaches and flushing

Those chasing strength or fat-loss goals value steady energy over quick spikes