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Another area of increasing interest is the signaling role of astrocytic lactate beyond its role as an energy substrate: emerging evidence demonstrates that lactate induces histone lysine lactylation (e.g., H3K18la), activating transcription factors like Klf4 to regulate genes associated with synaptic plasticity (e.g., Arc, CREB), thereby contributing to epigenetic remodeling during long-term memory formationa mechanism that underscores metabolic signaling as a target for cognitive enhancement (Yao et al., 2023)

10.1038/nchembio.2518 142 ZielonkaJ.JosephJ.SikoraA.HardyM.OuariO.Vasquez-VivarJ.et al (2017)

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Notably, both quercetin and resveratrol prevent iron-catalyzed hydroxyl radical formation, providing ferroptosis inhibition independent of Nrf2/ARE pathway

The table below summarises these findings: Liraglutide Liraglutide is another type of GLP-1 receptor agonist