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Previous studies have acknowledged the antioxidant properties of metformin 31,32,33

Increased levels of COHb lead to tissue hypoxia and brain damage

Meplan C, Richard MJ, Hainaut P

Persistent hyperglycemia and lipotoxicity synergistically exacerbate metabolic dysregulation through epigenetic modifications such as histone H3 lysine 27 acetylation (H3K27ac)