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The APP gene on chromosome 21, presenilin 1 (PSEN1) on chromosome 14, and presenilin 2 (PSEN2) on chromosome 1 have all been linked to the autosomal dominant type of the disease [90]

doi: 10.1038/tp.2011.60 270 MillerOShakespeare-FinchJBruenigDMehtaD

Aging Cell 23 (4), e14093

RET refers to a process where electrons flow in the opposite direction along the electron transport chain (ETC) compared with the typical oxidative phosphorylation process, leading to the generation of substantial amounts of ROS