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While the path forward for mRNA-based therapeutics may not be straightforward with challenges remaining, the immense potential of this technology is undeniable

However, despite intensive research efforts to elucidate the molecular mechanisms underlying the pathophysiology of PD, we still have a fragmented picture of the sequence of events that triggers the degeneration and death of dopaminergic neurons

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The 1940s brought advances in electron microscopy, providing the first high-resolution images of mitochondria

Drug Design, Development and Therapy , 10 (null), 17631770