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Description

Science 304 , 13281331 (2004)

Open Questions The clinical utility of Ivacaftor is limited to a small fraction of ~10% of CF patients, meaning that the largest segment of the CF population still awaits an etiological cure

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In general, the effect of direct binding of arsenic species to enzyme activity cannot be ruled out in toxicity-related investigations, where other factors like the reactive oxygen species are often implicated