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Disruption of CTCF/cohesin-mediated high-order chromatin structures by DNA methylation downregulates PTGS2 expression

This effect could be explained by the antioxidant potential of DMSO, instigating an enhancement in the endogenous antioxidant potential of cells, however the increase in DMSO concentration may cause it to be pro-oxidant and cytotoxic

Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD

10.1016/j.bios.2020.112733 375 WuY.GuS.CobbJ

In particular, proton pump inhibitors (PPIs, a class of drugs used to treat gastroesophageal reflux and peptic ulcer) may contribute to the progression of eosinophilic esophagitis by hindering the digestion of food allergens, contributing to impaired gut barrier function that leads to the absorption of undigested food allergens, and causing microbiome imbalance