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In keeping with this observation, here we unveil a crucial role of GSH in lipid production, as the synthesis of GSH, specifically in the liver, is required for sustaining physiological circulating triglyceride levels (an important energy source) and adipose tissue homeostasis under standard dietary regimen

3.1.2 Expression and regulation of key enzymes Acyl-CoA synthetase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3) are key enzymes that modulate phospholipid synthesis and remodeling

Later studies found similar patterns in Alzheimer's disease, Parkinson's disease, and COVID-19

We predicted that, at higher PDI concentrations, a 1-Cys mechanism gets more predominant over a 2-Cys mechanism since, under such conditions, reduced PDI should more likely win the race of nucleophilic attack to a sulphenylated C P against the C R residue of the same GPx7 molecule (Fig

16 Among them, protein tyrosine phosphatase 1B (PTP1B) is a widely expressed non-receptor PTP, which is associated with the endoplasmic reticulum by interaction through the C-terminal domain