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In biological systems, this lack of binding affinity prevents rapid clearance, resulting in a half-life approximately 120 times longer than endogenous IGF-1

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& Zheng, Y

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Alba and colleagues showed this albumin binding extends the half-life, such that once-daily administration sustained growth-hormone and IGF-1 profiles in animal models, [3] and Teichman and colleagues measured a half-life of roughly 5.8 to 8.1 days for CJC-1295 with DAC in humans, with sustained dose-dependent elevation of GH and IGF-I