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(4) Patients with confirmed resistance to entecavir or reduced glutathione, as evidenced by prior treatment failure, documented drug resistance mutations, or lack of clinical response to these drugs in past therapies

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Notably, these disturbances may persist even after treatment in about 6080% of cases, as observed in long-term survivors of CO CP [133, 134]

(Advises that if a dose is missed, take it as soon as possible unless its almost time for the next dose, in which case skip the missed dose

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