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Activation of mTORC1 signaling in gastric X/A-like cells induces spontaneous pancreatic fibrosis and derangement of glucose metabolism by reducing ghrelin production

M.RajaM.KahangiF

At the cellular interface, dermal fibroblasts regulate spreading, migration, and extracellular matrix (ECM) turnover through integrin-dependent adhesion signaling (e.g., FAK/ERK pathways), which is central to fibroblastECM homeostasis [48]

By incorporating cells that retain the molecular and functional features of the native tissue, these platforms allow researchers to reproduce patient specific disease mechanisms and treatment responses in vitro