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The effects of iron deficiency in tissues and reduced activity of iron-containing enzymes, such as growth retardation, abnormal behavior, and physical deficiency, can therefore be gradually corrected after active iron supplementation in iron-deficient animals, in addition to accelerating hemoglobin synthesis

Importantly, this study differs from previous research in its experimental design

This might be responsible for the low IGF-I levels seen in association with states of insulin resistance, as the metabolic syndrome[301]

Proc Natl Acad Sci U S A 95:84048409 Biterova EI, Barycki JJ (2009) Mechanistic details of glutathione biosynthesis revealed by crystal structures of Saccharomyces cerevisiae glutamate cysteine ligase

Sulfhydril groups present on plasma proteins can act as antioxidants by donating an electron to neutralize a free radical