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Suppression of RANKL-dependent heme oxygenase-1 is required for high mobility group box 1 release and osteoclastogenesis

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However, the growing awareness of interactions between glutathi- one and TRX systems (Michelet et al., 2005

Hemolysis: heme and iron release Repeated cycles of sickling/unsickling lead to the fragilization of the RBC membrane and thus to hemolysis that results in the release of extracellular hemoglobin, free heme, and free iron, all highly toxic to the vasculature by triggering vascular oxidative burden [22,137,138]

10.1155/2018/8234906 111 LuciusA.ChhatwalS.ValtinkM.ReinachP