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Individuals addicted to benzos may experience the following negative side effects increased reaction time, motor incoordination, anterograde amnesia, slurred speech, restlessness, delirium, aggression, depression, hallucinations, and paranoia. These negative side effects rarely lead to overdose, but when mixed with other drugs, individuals have a higher instance of negative side effects

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Splitting doses also dilutes the fasted-state metabolic advantage the evening dose occurs during fed state when insulin is elevated, reducing fat oxidation efficiency