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doi:10.1016/j.tree.2022.04.006

Both drugs are being developed by Novo Nordisk, likely reflecting a portfolio strategy: CagriSema as the first-to-market injectable combination, and amycretin as a follow-on oral option for patients who prefer pills

After obtaining the Cartesian_ddG and Flex_ddG data, variants showing improved stability and binding affinity were manually checked for pAcF orientation