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Future perspectives and challenges In situ cancer vaccination represents a transformative immunotherapeutic strategy that leverages the tumor itself as a source of antigens and immune stimulation, bypassing the need for predefined antigen identification and enabling broad immune responses against tumor-associated and neoantigens

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The addition of the AHK-Cu complex may potentially have stimulated the proliferation of normal dermal fibroblasts and possibly enhanced their viability

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They argue that the appropriate response is not a blanket ban but a structured framework: quality-controlled compounding, mandatory prescriber oversight, and data collection that builds the evidence base over time