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Several studies have shown that prophylactically lithium can reduce manic relapses, even if its efficacy is significantly lower in the reduction of depressive relapses 18

These two pathways converge

Actionable Insights (with effect sizes) For a scientifically literate self-experimenter, the honest take-home is that this is a mechanism paper, not a health-outcome paper no human or animal was dosed and followed for any clinical endpoint

The group receiving the combined treatment experienced a 15.6% reduction in weight loss, while the groups receiving treatment with cagrilintide or semaglutide experienced an 8.1% and 5.1% reduction in body weight, respectively [2]