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Studies have shown that nuclear cGAS binds to nucleosomes (mainly H2A-H2B), which prevents the cGAS-DNA binding and cGAS dimerization, thereby maintaining cGAS in an inactive conformation and consequently limiting autoreactivity (3234)

Flotillin-1 mediates PrP C endocytosis in the cultured cells during Cu 2+ stimulation through molecular interaction

Add-back therapy with norethindrone acetate is recommended to avoid serious long-term sequelae (36)

These antimicrobials are also less likely to cause resistance in microbes and are suitable for long-term use, such as in food preservation

Regular exercise reduces the expression of A and P-tau proteins in AD mice, enhances brain energy metabolism, restores mitochondrial function, and improves spatial learning and exploratory abilities (Pang et al., 2019)