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A greater proportion of lean NAFLD patients had PNPLA3 rs738409 (G/G) genotype (12 out of 33 vs 5 out of 38, p 0.05)

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However, none of the therapeutic candidates have been successful so far [10-12] , with the major impediment for most being a failure to cross the blood-brain barrier

Interestingly, even infectious entities with little to no CNS penetrance can stimulate inflammatory responses within the brain parenchyma, suggesting a role for systemic inflammation in the etiopathogenesis of neuroinflammation