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While clinically useful, this classification has been increasingly questioned due to its reliance on arbitrary time cutoffs and its inability to reflect the underlying biological diversity of resistance mechanisms [11,12,13]

In clinical trials, participants on the highest dose lost nearly 30% of their body weight in 68 weeks, substantially more than either semaglutide or tirzepatide achieved

[213] Wang J, Liu Z

In fact, features from acetone, tetrahydroisoquinoline derivative and 2-ethyl-1-hexanol were selected as discriminants of asthma with other coexisting atopic diseases