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The increase in resistance of pulmonary arterioles, produced by the hypoxia-induced rise in arterial smooth muscle cell tone, is associated with the modulation of different ion channels activity

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Diabetes 17:61-66 Mabedy GF, Wait GA, Kilpatrick JA, Loten EG, Gain KR, Ste- wart RDH, Eastman CJ (1982) Evidence for insulin degradation by muscle and fat tissue in an insulin resistant diabetic patient

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These peripheral and central deficits can include severe gastrointestinal lesions, intracranial (superior sagittal sinus) hypertension, brain swelling and lesions, portal and caval hypertension, aortic hypotension, peripheral and central thrombosis, inferior caval vein and superior mesenteric vein congestion, azygos vein failure, electrocardiogram (ECG) disturbances, and heart, lung, liver, and kidney lesions (Vukojevic et al., 2018