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ATF3 also enhances M2 (anti-inflammatory) macrophage program through indirect pathways

Clinical observations indicated that caution should be exercised when prescribing antidepressants, as misuse could lead to or worsen metabolic dysregulation (254, 255)

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Downstream metabolites of glucose/lactate are ultimately used to generate ATP (the principal energy source for CNS cells) or engage in metabolite signaling [57]