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First, the crosstalk network between distinct ferroptosis-regulating pathways (System Xc GSHGPX4 axis, lipid peroxidation, iron metabolism, and epigenetic regulation) remains poorly definedwhether these pathways act in a hierarchical, synergistic, or compensatory manner in different phases of I/R injury (ischemia vs

Koenig G, Seneff S

Choline contributes to normal fat metabolism

In cell culture models of human macrophage foam cells, the inability to clear cholesterol from macrophages with compromised lysosome function continues even in the presence of compounds that stimulate efflux (161,163)

Deeply elucidating these immune mechanisms is essential for developing novel prevention and treatment strategies