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Neoantigens can be divided into two types: shared neoantigens and personalized neoantigens (Tureci et al., 2018

A combined approach should be guided by a healthcare professional and monitored with appropriate labs

Tumour mutational burden LCINS generally have a markedly lower TMB (measured as non-synonymous mutations per megabase (mut/Mb)) in coding and non-coding regions compared to smoking-related lung cancers, with early studies suggesting as much as a tenfold difference 131 and a doseresponse relationship between TMB and pack-years 132 (Table 1)

This process triggers intracellular signaling cascades, leading to increased NLRP3 expression, promotion of myocardial fibrosis, and further acceleration of the progression of atrial fibrillation

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