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Casgevy and Lyfgenia: two gene therapies for sickle cell disease

In persons with hemolytic-uremic syndrome, the red blood cell structure is different, and evidence of impaired renal function will be seen

Additionally, we decided to evaluate the activity of a synthetic analogue of the LL-37 peptide, namely the WLBU2 peptide (RRWVRRVRRWVRRVVRVVRRWVRR), consisting mainly of Arg (13 residues) and Val (8 residues), with 3 Trp residues on the hydrophobic side, separated by at least 7 amino acids to optimize its activity in blood (Deslouches et al., 2005), and the VFR12 (VFRLKKWIQKVI) peptide, which is derived from thrombin, taking into account the fact that coagulation disorders occur in sepsis (Kasetty et al., 2011) and it can be assumed that its concentration increases with sepsis development

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This system operates in different cell compartments and genes, encoding its components are differentially regulated according to the current needs