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The pro-inflammatory cytokines (TNF-, IL-6, IL-8, E-selectin) and adhesion molecules (VCAM-1 and ICAM-1) stimulated by NF-B are implicated in the development of ECD [152, 153]

10.1038/emboj.2012.165 23 Kretz-RemyC.MehlenP.MiraultM

10.1165/rcmb.2006-0478OC 26 MaugA

Patients develop early-onset neurological manifestations and neurodevelopmental disorders that are currently incurable (Falk, 2010)

The recommended approach is to aliquot the reconstituted solution into single-use portions before freezing, minimizing repeated thermal cycling of the main research stock