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Ceelie I, James LP, Gijsen V, et al

Research dose/evidence: Some cosmetic studies show Acmella extract (the source of spilanthol) improves wrinkle appearance, but there are fewer large clinical trials than for retinoids or peptides (there never are with botanical extracts)

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2014;32(15_suppl):3548

Integrating modern chronobiology with traditional chronomedicine offers a promising path toward more precise and effective interventions, with the potential to improve post-stroke recovery and long-term outcomes