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Bevacizumab, an anti-VEGF therapy, has been shown to enhance the effects of radiation and chemotherapy, though its ability to extend survival has been limited [58]

It is foundational to cellular health, and its depletion is a consistent feature of chronic disease, aging, oxidative stress, and toxic burden

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Arch Biochem Biophys 433:166175 Banerjee R, Zou CG (2005) Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor protein