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2 Pathological characteristics and pathogenesis of blue light damage in the eyes 2.1 Pathophysiological characterization The pathways of blue light damage mainly include oxidative stress, endoplasmic reticulum stress and oxidative DNA damage, inflammatory response, mitochondrial damage and cell apoptosis, lysosomal autophagy and vascular endothelial damage (Zhang H

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The uncontrolled use of antibiotics in agriculture and inappropriate therapeutic practices has provided an evolutionary advantage to bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), and others that have become resistant to one or multiple types of antibiotics, contributing to the dramatic situation in healthcare (Figure 2)

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Glutathione depletion and oxidative stress