glutathione protandim parkinson' Frontiers Sulforaphane potently activates the Nrf2

10.1038/cdd.2009.107 Cell Death Differ

For metabolite assignments, two-dimensional NMR spectra including 1 H 1 H COSY, 1 H 1 H TOCSY, 1 H J -resolved, 1 H 13 C HSQC and 1 H 13 C HMBC for typical samples were acquired and processed as described previously [49]

L., De, Marco, M

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Furthermore, it has been described that ALA induces mitochondrial biogenesis by increasing the SIRT1 and PGC1 expression, which have neuroprotective properties, reducing oxidative stress, inflammation and preventing cell death [85, 86].The inhibition of PPAR using T0070907 [87, 88], avoided the beneficial effect of ALA, suggesting that PPAR activation is at least one of the key mechanisms through which ALA ameliorates the mutant phenotype of FRDA fibroblasts