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Serum GPNMB levels in the NASH mouse model showed a high positive correlation with GPNMB and COL1A1 gene expression levels in liver tissue

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This study brought about the hypothesis that MeHg may be transported from the blood to the CNS across the blood-brain barrier (BBB) by the L-type neutral amino acid carrier transport (LAT) system

Moreover, exogenous acetate was observed to reverse CIA mice with exacerbated gut microbial disruption, thereby further confirming the crucial role of the effect of gut microbial metabolite acetate on neutrophils in vivo in immune regulation (Jin et al., 2023