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The Taiwan Adverse Drug Reaction Reporting System for Herbal Medicine (TADRRS-HM) database reported the most important causes for adverse reactions to herbal medicine, among which: incorrect processing techniques, improper mixing dosages, harmful interactions between different herbs, wrong methods of decoction, but also the inappropriate indications or dosage, a mismatch between the prescribed formula and the disease pattern can be responsible for adverse effects, other than individual factors such as the individuals organism characteristics or immune system status, are important

However, the physiological substrates of OCTN1 are still matter of discussion (Pochini et al., 2019 and Table 1)

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