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GLP-1 Receptor Agonists Semaglutide and tirzepatide are technically peptide-based therapeutics

First of all, intracellular iron generally exists in the form of Fe 2+ , which can produce OH through the Fenton reaction, and then react with polyunsaturated fatty acids in the plasma membrane to produce ROS, resulting in iron-regulated death

ROC analysis based on pathway scores revealed that pathways such as alanine, aspartate, and glutamate metabolism, inositol phosphate metabolism, and mitochondrial beta-oxidation of unsaturated fatty acids exhibited an AUC greater than 0.8 in the PBMC data (Table S16)

This combination is effective for SIFO as well

Research assessing muscle and tendon healing reported increases in angiogenic markers such as VEGF, CD34, and factor VIII in injured tissue following peptide exposure [6]