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AMPK Activation as the Core Mechanism Berberine activates AMP-activated protein kinase (AMPK) in hepatocytes and skeletal muscle, a pathway that overlaps meaningfully with metformin [5]

[ 106 , 107 , 108 ] In an accelerated aging mouse model, the accumulation of BACH1 in the nucleus increases under H 2 O 2 treatment in embryonic fibroblasts