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Changes in IGFBPs have been correlated with certain parameters of MetS

Mean total Sharp score (mTSS) progression for the placebo group in this trial was small relative to what has been seen in RA (approximately 1 unit over 48 weeks), but this progression was clearly greater than in the etanercept group, where there was no mean total Sharp progression at both 24 and 48 weeks (Figure 7-5)