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In summary, the pathological mechanisms of CCVDs primarily involve endothelial dysfunction, inflammatory responses, oxidative stress and cell necrosis or apoptosis (201-203)

10.1038/ng0197-62 Summary Keywords antioxidants, calcium channel, neurodegenerative disorders, oxidative stress, potassium channels, reactive oxygen species, sodium channels, glutathione Citation Orfali R, Alwatban AZ, Orfali RS, Lau L, Chea N, Alotaibi AM, Nam Y-W and Zhang M (2024) Oxidative stress and ion channels in neurodegenerative diseases

Glutathione acts as an antioxidant by neutralizing free radicals and reactive oxygen species

10.3390/ijms241612666 38 HuangM.XiaoM.DongJ.HuangY.SunH.WangD

Notably, since GSH is also an essential component in the synthesis of metal-binding peptides such as PCs, GSH has been the major metabolic/biochemical modulator of of PCs (Hall, 2002