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This adjustment is justified by the evidence that these mutations, typically associated with AML evolving from an antecedent hematologic disease, can also be detected in de novo AML and confer adverse risk even in the absence of MR morphological features and/or a prior history of MDS

SDH plays a key role in mitochondrial metabolism both as a member of the electron transport chain and the TCA cycle ( G

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136 In addition, acquired astrocytopathies are prominent in hepatic encephalopathy (in which astrocytes lose their homoeostatic capabilities 137 ) and in neuromyelitis optica, in which the astrocyte protein, AQP4 is the subject of autoimmune attack, leading to dysfunction and death of astrocytes resulting in pronounced inflammation and degeneration of neural tissue