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Once endocytosed, the lipid nanoparticles promote endosomal escape, and release their genetic cargo in the cytosol, where the mRNA is translated into antigenic proteins, kick-starting the immune system machinery into producing neutralizing antibodies

Broken hearts: Iron overload, ferroptosis and cardiomyopathy

doi: 10.1016/j.cej.2024.158050 308 JayaramHKolkoMFriedmanDSGazzardG

As an attractive target for regulating macrophage metabolism, unlike RONS, which have been extensively studied, researchers need to explore NM-modulated succinate oxidation to address this gap in our understanding of defense against diseases