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Eur J Immunol (2009) 39:160818

Kelch-like ECH-associated protein 1 (Keap1) protein contains multiple highly reactive cysteine residues (such as Cys151, Cys273, Cys288), and its persulfidation modification disrupts the binding between Keap1and Nuclear factor erythroid 2-related factor 2 (Nrf2), leading to Nrf2 stabilization and nuclear translocation to initiate antioxidant gene expression ( 2 S can inhibit PTP1B phosphatase activity by inducing persulfidation ( 2 S inhibits abnormal differentiation of Th17 cells by persulfidating cysteine 38 of selenoprotein F, thereby maintaining immune homeostasis and preventing autoimmune diseases ( 2.4 Interactions of RSS with ROS/RNS RSS do not operate independently but constitute an interconnected redox regulatory network with ROS and RNS

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Shin T-H, Sung E-S, Kim Y-J, Kim K-S, Kim S-H, Kim S-K, et al