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This creates oxidative stress, ROS formation, and eventual collagen deposition, which leads to fibrotic formation in the RV ( Galectin-3 (Gal-3), a biomarker for LV remodeling, has been shown to interact with NOX4-derived oxidative stress promoting cardiac fibrosis in the RV in PH patients (Wang X

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Patients can move between normal, hyper, and hypothyroid patterns before permanent underactivity develops

Sex differences have also been found in cultured cells

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