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Serum IGF-I levels in the fourth patient who had a relatively mild phenotype were also variable and not severely decreased (Netchine et al., Genetic analysis of IGF1 in the second case (Bonapace et al., IGF1 revealed a homozygous missense mutation resulting in the change of a highly conserved arginine located in the C domain of the protein into a glutamine (p.R36Q)

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