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Studies on endometriosis have shown that metformin exerts potent anti-NF-B effects, alleviating disease progression, and it has demonstrated the potential to target pro-inflammatory molecules in endometriotic cells (Takemura et al., 2007), macrophages, and vascular smooth muscle cells in vitro (Isoda et al., 2006), in obese mice (Hyun et al., 2013), and in rat models of endometriosis (Jamali et al., 2021

J Endocrinol 204:165172 Zhu HJ, Wang X, Pan H, Gong F, Zhang D, Li N, Wang L, Yang H (2014) Serum levels of the adipokine zinc-2-glycoprotein are decreased in patients with hypertension

In a field study, supplemental UV-B increased SOD activity in wheat and mungbean, and caused differential responses among soybean cultivars (Agrawal et al., 2010)

Targeted nanocarriers of 2C5 and DNase I can target NETs and have clinical implications for the targeted removal of NETs (248)