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& Rajh, T

Medications such as metformin (used for diabetes), which interferes with vitamin B12 absorption

The clinical benefits were greatest in those who took folic acid for more than 12 weeks and those whose homocysteine levels dropped by more than 25%

The pathophysiology of depression remains incompletely understood, with antidepressants based on the monoamine hypothesis currently representing the most common treatment for depressive episodes