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For example, the oxidation of Cu I by electronically excited Re I is 100-fold faster than single-step ET due to the transient oxidation of W122, which was confirmed in case of azurin protein from Pseudomonas aeruginosa [20]

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Additionally, halogenated pyrimidine nucleosides have recently been shown to increase target protein expression by 510 fold [30], while phosphorothioate modifications upstream of the start codon may facilitate ribosomal complex assembly [31]

To help bypass any barriers to absorption in the GI tract, many healthcare providers recommend B12 injections for deficiency, but research shows that very high doses of oral B12 (1,000 to 2,000 mcg once a day) can normalize serum B12 levels to a similar extent with minimal side effects