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The effect of vitamin E on GPXs activity dlAlphatocopherol (vitamin E) also is an antioxidant, but it is different from selenium acting on GPX directly, vitamin E plays its antioxidant function through combining free radical, named chainbreaking reaction. Vitamin E was considered to be the first line of defense against lipid peroxidation and free oxygen radicals that might suppress the enzymes, such as GPX

We also used homozygous APOE3 and APOE4 mice, which do not reflect the full spectrum of APOE allele combinations in humans (Hana Saddiki et al., 2020)