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Because sample sizes in individual studies were small, single studies were not considered a sufficient and reliable evidence base from which to construct an evidence-based statement (i.e., a Standard, Recommendation, or Option)

The FDA has granted orphan drug designation to Tesomet for the treatment of Prader-Willi syndrome

Contraindications and cautions Researchers should exercise caution in several scenarios

Many people are deficient in one or more B vitamins due to factors such as diet, poor absorption, or lifestyle habits, and injections offer an efficient way to restore balance

doi: 10.1016/j.semarthrit.2016.08.012 17 ZachrissonO.ReglandB.JahreskogM.KronM.GottfriesC