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10.1016/j.fertnstert.2008.09.065 28

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Moreover, various drugs and interventions, including natural compounds, enzymes from animal or plant sources [246,247,248,249,250,251,252], microbiota and derivatives [253,254,255], endogenous steroids [256, 257], and exercise [258], have been implicated in modulating the IGF pathway and potentially improving pathology and cognitive function in animal models of AD