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Selenoprotein P (SELENOP) and GPx are two of the antioxidant enzymes that assimilate Se NMs as selenocysteine (SEC)

Overall, there was a transient increase in serum creatinine observed within 10 days of dosing in 1.8% of Reclast-treated patients versus 0.8% of placebo-treated patients which resolved without specific therapy [see Warnings and Precautions (5.3)]